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Understanding MTHFR Gene Mutations
MTHFR (methylenetetrahydrofolate reductase) gene mutations can lead to elevated homocysteine levels, increasing the risk of cardiovascular diseases, neural tube defects, and mental health issues. Managing these mutations through diet and lifestyle is crucial.
20% - 40% of south asians have MTHFR mutations.
There is an obvious correlation among MTHFR 1298C & stroke risk in south asians.
Common MTHFR Gene Mutations
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C677T Mutation: Reduces MTHFR enzyme activity, leading to higher homocysteine levels.
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A1298C Mutation: Affects enzyme activity but generally to a lesser extent.
Health Implications
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Elevated Homocysteine Levels: Increased risk of cardiovascular diseases, blood clots, and pregnancy complications.
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Neural Tube Defects: Higher risk for pregnant women.
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Mental Health Issues: Associations with depression, anxiety, and other disorders.
Case Scenario:
Sana, a 30-year-old with a BMI of 25 and a diagnosis of elevated homocysteine levels, underwent genetic testing revealing a C677T mutation in the MTHFR gene. Her diet was low in folate and B vitamins, with lack of physical activity.
To manage her condition, a personalized plan was created:
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Increase Folate-Rich Foods: Incorporating leafy greens, citrus fruits, beans, and fortified cereals into her diet.
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Vitamin B6 and B12 Rich foods: Ensuring adequate intake through diet as needed.
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Lifestyle Changes: Incorporating physical activity to support better homocysteine metabolism.
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Ayurvedic Principles: Incorporation of ayurvedic principles according to doshas.
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Regular Monitoring: Periodic blood tests to monitor homocysteine levels and adjust the diet accordingly.
By understanding the specific needs and health risks associated with MTHFR gene mutations, FAM generates a personalized NutriKart tailored to your genetic profile. This ensures you receive the right balance of nutrients, promoting optimal health and reducing the risks associated with elevated homocysteine levels.